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m5C Methylation Guides Systemic Transport of Messenger RNA over Graft Junctions in Plants

m5C甲基化指导系统中移植物上信使RNA的系统转运

关键词:
来源:
Current Biology期刊
全文链接1:
http://agri.ckcest.cn/topic/downloadFile/13540bc0-d913-4330-9b67-d73e7c83e024
全文链接2:
https://www.cell.com/current-biology/fulltext/S0960-9822(19)30769-9
类型:
学术文献
语种:
英语
原文发布日期:
2019-07-18
摘要:
In plants, transcripts move to distant body parts to potentially act as systemic signals regulating development and growth. Thousands of messenger RNAs (mRNAs) are transported across graft junctions via the phloem to distinct plant parts. Little is known regarding features, structural motifs, and potential base modifications of transported transcripts and how these may affect their mobility. We identified Arabidopsis thaliana mRNAs harboring the modified base 5-methylcytosine (m5C) and found that these are significantly enriched in mRNAs previously described as mobile, moving over graft junctions to distinct plant parts. We confirm this finding with graft-mobile methylated mRNAs TRANSLATIONALLY CONTROLLED TUMOR PROTEIN 1 (TCTP1) and HEAT SHOCK COGNATE PROTEIN 70.1 (HSC70.1), whose mRNA transport is diminished in mutants deficient in m5C mRNA methylation. Together, our results point toward an essential role of cytosine methylation in systemic mRNA mobility in plants and that TCTP1 mRNA mobility is required for its signaling function.
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