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Dietary supplement with nucleotides in the form of uridine monophosphate or uridine stimulate the intestinal development and promote nucleotide transport in weaned piglets

含有尿苷一磷酸或尿苷形式的核苷酸的膳食补充剂刺激肠道发育并促进断奶仔猪的核苷酸转运

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来源:
Wiley Online Library
类型:
学术文献
语种:
英语
原文发布日期:
2019-06-08
摘要:
AbstractBACKGROUNDNucleotides are key constituents of milk, where they are utilised in cell replication, although there are limited studies in the weaned piglets. This study evaluated the effects of uridine monophosphate (UMP) with uridine (UR) feed supplementation on the intestinal development and nucleotide transport in weaned piglets. RESULTSSupplementation with UMP significantly increased (P < 0.05) plasma glucose, and UR supplementation significantly reduced (0.05 < P < 0.10) the plasma total cholesterol (TC) of piglets when compared with that in the control group, although non‐significant difference (P > 0.05) in growth performance was observed among three groups. Piglets fed supplementary UR exhibited greater (P < 0.05) crypt depth in the duodenum and ileum when compared with those in the supplementary UMP and control groups. RT‐qPCR results revealed that UR supplementation increased (P < 0.05) the relative mRNA levels of genes encoding the transmembrane proteins ZO‐1 and occludin in the duodenum mucosa, and ZO‐1 in the jejunum mucosa (P < 0.05). Similarly, UR supplementation increased (P < 0.05) expression of solute carriers SLC28A1 and SLC29A1 in the duodenum mucosa. Conversely, claudin‐1 expression in the duodenum mucosa was inhibited (P < 0.05) by dietary supplementation with UMP or UR. CONCLUSIONCollectively, our data indicated that dietary supplementation with UMP or UR was conducive to stimulating the intestinal development and promoting nucleotide transport in weaned piglets.
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